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1

A Class of Diacylglycerol Acyltransferase 1 Inhibitors Identified by a Combination of Phenotypic High-throughput Screening, Genomics, and Genetics

Tschapalda, Kirsten, Zhang, Ya-Qin, Liu, Li, Golovnina, Kseniya, Schlemper, Thomas, Eichmann, Thomas O., Lal-Nag, Madhu, Sreenivasan, Urmila, McLenithan, John, Ziegler, Slava, Sztalryd, Carole, Lass,

Journal:

Year:

2016

Language:

english

File:

PDF, 3.35 MB

english, 2016

2

The claudins

Madhu Lal-Nag, Patrice J Morin

Journal:

Year:

2009

Language:

english

File:

PDF, 419 KB

english, 2009

3

Claudin-6: a novel receptor for CPE-mediated cytotoxicity in ovarian cancer

Lal-Nag, M, Battis, M, Santin, A D, Morin, P J

Journal:

Year:

2012

Language:

english

File:

PDF, 1.63 MB

english, 2012

4

Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy

Kenny, Hilary A., Lal-Nag, Madhu, White, Erin A., Shen, Min, Chiang, Chun-Yi, Mitra, Anirban K., Zhang, Yilin, Curtis, Marion, Schryver, Elizabeth M., Bettis, Sam, Jadhav, Ajit, Boxer, Matthew B., Li,

Journal:

Nature Communications

Year:

2015

Language:

english

File:

PDF, 1.19 MB

english, 2015

5

Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1)

Yang, Shyh-Ming, Yasgar, Adam, Miller, Bettina, Lal-Nag, Madhu, Brimacombe, Kyle, Hu, Xin, Sun, Hongmao, Wang, Amy, Xu, Xin, Nguyen, Kimloan, Oppermann, Udo, Ferrer, Marc, Vasiliou, Vasilis, Simeonov,

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 773 KB

english, 2015

6

Microfluidic Mobility Shift Profiling of Lysine Acetyltransferases Enables Screening and Mechanistic Analysis of Cellular Acetylation Inhibitors

Sorum, Alexander W., Shrimp, Jonathan H., Roberts, Allison M., Montgomery, David C., Tiwari, Neil K., Lal-Nag, Madhu, Simeonov, Anton, Jadhav, Ajit, Meier, Jordan L.

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 1.55 MB

english, 2015

7

Large-scale pharmacological profiling of 3D tumor models of cancer cells

Mathews Griner, Lesley A, Zhang, Xiaohu, Guha, Rajarshi, McKnight, Crystal, Goldlust, Ian S, Lal-Nag, Madhu, Wilson, Kelli, Michael, Sam, Titus, Steve, Shinn, Paul, Thomas, Craig J, Ferrer, Marc

Journal:

Cell Death and Disease

Year:

2016

Language:

english

File:

PDF, 3.68 MB

english, 2016

8

RNAi High-Throughput Screening of Single- and Multi-Cell-Type Tumor Spheroids: A Comprehensive Analysis in Two and Three Dimensions

Fu, Jiaqi, Fernandez, Daniel, Ferrer, Marc, Titus, Steven A., Buehler, Eugen, Lal-Nag, Madhu A.

Journal:

Year:

2017

Language:

english

File:

PDF, 1.89 MB

english, 2017

9

Erratum: Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy

Kenny, Hilary A., Lal-Nag, Madhu, White, Erin A., Shen, Min, Chiang, Chun-Yi, Mitra, Anirban K., Zhang, Yilin, Curtis, Marion, Schryver, Elizabeth M., Bettis, Sam, Jadhav, Ajit, Boxer, Matthew B., Li,

Journal:

Nature Communications

Year:

2016

Language:

english

File:

PDF, 296 KB

english, 2016

10

1104 High-throughput small-molecule and RNAi screens identify Aurora kinase B inhibitors as a novel treatment for Merkel cell carcinoma

Gelb, T., Urban, D., Coxon, A., Gryder, B., Xiao, Y., Glavin, R., Chakka, S., Lee, O., Shen, M., Lal-Nag, M., Hall, M., Brownell, I.

Journal:

The Journal of Investigative Dermatology

Year:

2018

Language:

english

File:

PDF, 242 KB

english, 2018

11

Translational in vitro research: integrating 3D drug discovery and development processes into the drug development pipeline

Kelm, Jens M., Lal-Nag, M., Sittampalam, G.S., Ferrer, Marc

Journal:

Drug Discovery Today

Year:

2018

Language:

english

File:

PDF, 916 KB

english, 2018

12

Identifying new engineering targets in Chinese hamster ovary cells

Klanert, G., Daniel, F., Weinguny, M., Eisenhut, P., Bühler, E., Melcher, M., Titus, S., Jadhav, V., Su, X., Beate, S., Lal-Nag, M., Shiloach, J., Borth, N.

Journal:

New Biotechnology

Year:

2018

Language:

english

File:

PDF, 71 KB

english, 2018

13

CLDN10 (claudin 10)

Journal:

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Year:

2012

Language:

english

File:

PDF, 774 KB

english, 2012

14

Quantitative high-throughput screening using an organotypic model identifies compounds that inhibit ovarian cancer metastasis.

Kenny, Hilary A, Lal-Nag, Madhu, Shen, Min, Kara, Betul, Nahotko, Dominik A, Wroblewski, Kristen, Fazal, Sarah, Chen, Siquan, Chiang, Chun-Yi, Chen, Yen-Ju, Brimacombe, Kyle R, Marugan, Juan, Ferrer,

Journal:

Molecular Cancer Therapeutics

Year:

2019

Language:

english

File:

PDF, 2.13 MB

english, 2019

15

Quantitative high-throughput screening using an organotypic model identifies compounds that inhibit ovarian cancer metastasis.

Kenny, Hilary A, Lal-Nag, Madhu, Shen, Min, Kara, Betul, Nahotko, Dominik A, Wroblewski, Kristen, Fazal, Sarah, Chen, Siquan, Chiang, Chun-Yi, Chen, Yen-Ju, Brimacombe, Kyle R, Marugan, Juan, Ferrer,

Journal:

Molecular Cancer Therapeutics

Year:

2019

File:

PDF, 2.13 MB

2019

16

A 3D Heterotypic Multicellular Tumor Spheroid Assay Platform to Discriminate Drug Effects on Stroma versus Cancer Cells

Weydert, Zoe, Lal-Nag, Madhu, Mathews-Greiner, Lesley, Thiel, Christoph, Cordes, Henrik, Küpfer, Lars, Guye, Patrick, Kelm, Jens M., Ferrer, Marc

Journal:

Year:

2019

Language:

english

File:

PDF, 1.35 MB

english, 2019

17

A 3D Heterotypic Multicellular Tumor Spheroid Assay Platform to Discriminate Drug Effects on Stroma versus Cancer Cells

Weydert, Zoe, Lal-Nag, Madhu, Mathews-Greiner, Lesley, Thiel, Christoph, Cordes, Henrik, Küpfer, Lars, Guye, Patrick, Kelm, Jens M., Ferrer, Marc

Journal:

Year:

2019

File:

PDF, 1.35 MB

2019

18

Zinc-finger antiviral protein (ZAP) is a restriction factor for replication of modified vaccinia virus Ankara (MVA) in human cells

Peng, Chen, Wyatt, Linda S., Glushakow-Smith, Shira G., Lal-Nag, Madhu, Weisberg, Andrea S., Moss, Bernard, Wiebe, Matthew S.

Journal:

Year:

2020

File:

PDF, 13.18 MB

2020